Results
| PMID | 21075367 |
| Gene Name | POU5F1 |
| Condition | Endometriosis |
| Association |
Associated |
| Sex | Female |
| Associated genes | oct-4, c-kit |
| Other associated phenotypes |
Endometriosis |
|
Fertil Steril. 2011 Mar 1;95(3):1171-3. doi: 10.1016/j.fertnstert.2010.10.029. Pacchiarotti, Arianna| Caserta, Donatella| Sbracia, Marco| Moscarini, Massimo University of Rome Sapienza, Rome, Italy. arypac@alice.it The objective of this study was to test the expression of the oct-4 and c-kit, both markers of stem cells, in the ectopic endometrial tissue of endometriotic lesions of women with severe endometriosis. Our findings show that ectopic epithelial cells express oct-4 and c-kit and this suggests that the ectopic endometrium in endometriosis has a stem cell origin and could explain the possible progression to ovarian cancer. Mesh Terms: Biomarkers/metabolism| Biopsy| Disease Progression| Endometriosis/*metabolism/pathology| Female| Humans| Octamer Transcription Factor-3/*metabolism| Ovarian Neoplasms/*metabolism/pathology| Proto-Oncogene Proteins c-kit/*metabolism| Severity of I |
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